Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition
نویسندگان
چکیده
منابع مشابه
Epigenetic regulation of pluripotency and differentiation.
The precise, temporal order of gene expression during development is critical to ensure proper lineage commitment, cell fate determination, and ultimately, organogenesis. Epigenetic regulation of chromatin structure is fundamental to the activation or repression of genes during embryonic development. In recent years, there has been an explosion of research relating to various modes of epigeneti...
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TAR DNA-binding protein of about 43 kDa (TDP-43) is the main ubiquitinated peptide in tau-negative frontotemporal lobar degeneration (FTLD). TDP-43 is typically a nuclear protein, and its aggregation and cytoplasmic translocation are thought to represent major steps in the pathogenesis of FTLD due to TDP-43 proteinopathy (FTLD-TDP). Certain clinical syndromes of frontotemporal dementia are pref...
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NEUROPATHOLOGICAL PROTEIN TDP-43 Jayarama Krishnan Bose, Chi-Chen Huang and C.-K. James Shen Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China Running head: TDP-43 and Autophagy Address correspondence to: C.-K. James Shen, PhD, N523, Institute of Molecular Biology, Academia Sinica, 128 Academia Road, Sec 2, Nangang, Taipei-115, Taiwan, ROC. Tel: +886-2-2789-9194...
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Mutations in the human progranulin gene resulting in protein haploinsufficiency cause frontotemporal lobar degeneration with TDP-43 inclusions. Although progress has been made in understanding the normal functions of progranulin and TDP-43, the molecular interactions between these proteins remain unclear. Progranulin is proteolytically processed into granulins, but the role of granulins in the ...
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The budding yeast Saccharomyces cerevisiae is an emerging tool for investigating the molecular pathways that underpin several human neurodegenerative disorders associated with protein misfolding. Amyotrophic lateral sclerosis (ALS) is a devastating adult onset neurodegenerative disease primarily affecting motor neurons. The protein TDP-43 has recently been demonstrated to play an important role...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2019
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2019.03.041